The Molecular Mechanisms of the Vascular Etiology of Alzheimer’s Disease (M2OVE-AD) Consortium seeks to better understand how the vascular system may be involved in the onset and progression of AD and related dementias. Developed by the NIA and the NINDS, this program brings together over a dozen research teams working on five complementary projects.
The teams will generate several layers of molecular data from brain tissue donated by deceased Alzheimer’s research participants and from blood cells and plasma donated by living study participants with various types of vascular risk. Teams will develop mathematical models of the molecular processes that link vascular risk factors to Alzheimer’s onset and progression by combining molecular data with data on cognition, brain imaging and several measures of vascular health. In parallel, the teams will use a number of animal models that show different vascular disease traits to tease out the molecular mechanisms linking vascular risk factors and Alzheimer’s and to test the predictions made from the analysis of the human data. M2OVE-AD builds upon the open-science approach and the big-data infrastructure established by the Accelerating Medicines Partnership-Alzheimer’s Disease (AMP-AD).