Sage Bionetworks and the Institute for Systems Biology will partner to build the Cancer Research Institute iAtlas, an online database and web resource designed to help basic and clinical researchers navigate immunological data across multiple tumor types. The CRI iAtlas database is the first comprehensive effort in immuno-oncology to address the recent National Cancer Moonshot Blue Ribbon Panel recommendation to establish a pan-cancer immune atlas that would help catalyze new research in cancer immunotherapy.
The CRI iAtlas resource will be built on Sage’s Synapse platform for data management and sharing, while also leveraging the capabilities of ISB’s Cancer Genomics Cloud to enable immuno-oncology researchers to perform flexible data query and visualization. Its structured data repository will integrate multiple characterizations of the immune response in tumors made by a working group formed by The Cancer Genome Atlas, led by the U.S. National Institutes of Health. Data generated by the working group, which includes molecular profiling of over 10,000 tumors across 33 tumor types as well as a series of results on immune-tumor interaction and response mechanisms, will provide rich characterizations of the relationship between tumors and the immune microenvironment and its impact on patient outcomes.
“Insights derived from these data will be critical to improving the effectiveness of current cancer immunotherapy treatments and developing new immune-based treatment strategies,” said Justin Guinney, Ph.D., principal investigator, director of computational oncology and bioinformatics at Sage Bionetworks.