Sage Bionetworks Podcasts

Podcast: Play in new window | Download (Duration: 6:50 — 23.4MB) | Embed

Bas Bloem, Parkinson Net
I describe how research should transform from its traditional approach – where scientists dictate the research agenda and possess the data – to a new world of ‘Research 2.0’ or ‘participatory research’ where patients define what they feel is clinically most relevant, where patients own their own data, and where scientists collaborate in order to best answer the patients’ questions

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 5:43 — 18.5MB) | Embed

Phil Bourne, PloS ONE, SDSC
Much of science is closed and hierarchical. Occasionally something happens that really drives home how limiting that can be. Such is the story of Meredith. Citizen scientists typically contribute data to be interpreted by the experts. Garage scientists run their own experiments which occasionally make it big (think Apple). Enter “digger scientists” who turn apparent digital trash into treasure.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:35 — 22.9MB) | Embed

Geoffrey Clapp, Rock Health
Telemedicine has been slow to be adopted at “internet scale,” in many cases due to legislative hurdles and medical licensure. Several legislative changes are currently in progress that will not only make telemedicine more attractive, providing the rocket fuel to the telemedicine, opening up many new revenue sources for doctors and startups in the health/tech space, and better, more cost effective care for patients.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 7:00 — 25.2MB) | Embed

Magali Haas, One Mind
A dive into culture, values and data and other root causes and an exploration of potential solutions toward a lifetime of brain health.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:40 — 22.1MB) | Embed

Krishanu Saha, MIT
Embryonic-like stem cells can now be induced from routine blood samples from nearly any person.  These cells grown in Petri dishes may used to model disease in the individual and thus are called a “disease-in-a-dish”.  But has the individual been lost in this categorization?  I will describe how various individuals – researchers, doctors, patients, citizens, donor-participants, and future consumers of personalized medicine – emerge in the research architectures constituting this field.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:31 — 24.1MB) | Embed

Markus Warmuth, H3 Biomedicine
Lack of access to powerful and expansive experimental platforms and infrastructure essential for oncology target validation and continued hypothesis validation from the drug discovery process and up until clinical trial significantly hinders small or medium size biotechnology companies, research or academic institution’s capability to advance oncology drug discovery. We propose the idea of Translational Pre-Clinical Oncology  (TransPOC) Consortium, which seeks to establish translational infrastructure including experimental platforms and novel technologies for information/data sharing, mining capability and dynamic research/publishing through shared resources.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:55 — 24.0MB) | Embed

Aled Edwards, Structural Genetics Consortium
Bibliometric analysis of research activity reveals that most research in academic and industry is focused on 10% of human proteins, despite genetic evidence highlighting disease-related proteins in the “unstudied” 90%.  Even if we succeed in describing disease networks and in uncovering new targets, will the peer-review system allow us to study them?   Is our cherished peer-review system an anachronism?

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:15 — 31.2MB) | Embed

Larry Hunter, University of Colorado, Denver
Traditional analytics need defined outcomes to build predictive models. Theories of reinforcement learning, particularly temporal difference learning, have the potential to help patients use high-frequency phenotyping to manage their disease, maximizing diverse sets of positive events while minimizing negative ones.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 7:41 — 21.7MB) | Embed

Kathy Giusti, Multiple Myeloma Research Foundation
The emerging technological and digital revolution has had a significant impact on patients’ ability to advance progress toward personalized treatments and cures. I will provide examples of how the Multiple Myeloma Research Foundation is developing and implementing models and programs to leverage these opportunities

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:41 — 22.5MB) | Embed

Francois Grey, CERN
Like medieval guilds experts require long training and are paid well. Recent crowd sourcing methods have shown an alternative. Is there an opportunity for crowdsourcing parts of the expertise needed to treat patients?

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (18.8MB) | Embed

Heather Joseph, SPARC
There is a growing movement to change the lack of taxpayer’s access to scientific research by supporting policies that require all published results to be made available to the public, free, online as soon as possible. This talk will outline actions you can take to get involved and make taxpayer-funded science openly accessible.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:19 — 17.4MB) | Embed

Tom Insel, NIH
Translational science relevant to drug discovery has hit a wall.  When we shift our focus from “what science we do” to “how we do science”, several solutions emerge.  Perhaps most critical is the recognition that partnerships built around pre-competitive sharing of compounds, data, and resources can accelerate a key step in translation — target validation.  NIH via its new National Center for Advancing Translational Science (NCATS) can catalyze translation by changing “how we do science”

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:29 — 19.6MB) | Embed

Misha Angrist, Duke University
I discuss two experiences I have had as a member of the Duke IRB, both of which illustrate how far we are from changing the culture of academic research from one based on paternalism, genetic exceptionalism and legal liability to one based on autonomy and partnership. It’s hard to be optimistic sometimes.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 5:30 — 24.8MB) | Embed

Iya Khalil, GNS Healthcare
A near fatal bilateral pulmonary embolism has given me a unique perspective on the state of healthcare and what the biomedical community needs to achieve beyond sequencing our genomes to ultimately help the end consumer in this system – the patient

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 6:22 — 22.0MB) | Embed

Joseph Hellerstein, Google
Scientific discovery is in transition from a focus on data collection to an emphasis on analysis and prediction using large scale computation. These computations can be done with unused cycles in commercial Clouds if there is appropriate software support. This talk describes the Google Exacycle system that routinely provides more than 100K cores for scientists doing computation based discovery.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 5:59 — 18.8MB) | Embed

John Schrom, Rock Health
The average 24-year-old will spend more time on Facebook in the next week than they will spend with a physician in the next 20 years. I will provide examples of how our health is expressed through social media, how we can use that to improve lives and fight disease, and why this is the start of a transformational change in public health and medicine.

This presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 7:14 — 22.8MB) | Embed

Francois Taddei, INSERM Paris
Learning through research is a powerful educational tool that is often limited to students in research universities. Can open science, open technology, and open education converge as a force to democratize and reinvent how learning through research is done? I provide an example of ways forward that I would like to co-design with the sage community.

Dr. Taddei’s presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.

Podcast: Play in new window | Download (Duration: 11:30 — 43.6MB) | Embed

Susan Love, Susan Love Research Foundation
All efforts to revolutionize our approach to medical research are based on the same silos of researchers and physicians on one side and patients on the other. The term patient refers to what is usually experienced as a one down position. This is an artificial dichotomy since we are all patients or soon to be patients. This should be a public effort with all of us bringing our expertise to the table to work together to eradicate disease. Sometimes we may be wearing a doctor hat but we also may have a researcher and a patient hat…they really are not different groups. We are all now or soon to be patients!

Dr. Love’s presentation was part of the Congress Unplugged! event at the 2012 Sage Bionetworks Commons Congress.